This Chicken Bubble Biscuit Bake Casserole is classic comfort food at its best—creamy, cheesy, and loaded with tender chicken and fluffy biscuit pieces that puff up as they bake. Everything comes together in one dish, making it perfect for busy weeknights, potlucks, or feeding a hungry family with minimal effort.
As it bakes, the biscuit dough “bubbles” through the creamy sauce, creating soft, pillowy bites with golden tops. It’s cozy, filling, and always a hit.
Why You’ll Love This Casserole
- One-pan, easy dinner
- Creamy, cheesy, and comforting
- Uses rotisserie or leftover chicken
- Kid-friendly and crowd-pleasing
- Great for make-ahead meals
Ingredients
- 2 cups cooked chicken, shredded or diced
- 1 can (10.5 oz) cream of chicken soup
- ½ cup sour cream
- ½ cup milk
- 1½ cups shredded cheddar cheese
- 1 tsp garlic powder
- ½ tsp onion powder
- Salt and pepper, to taste
- 1 can refrigerated biscuits, cut into quarters
- 1 tbsp butter (optional, for greasing)
Optional Add-Ins
- ½ cup frozen peas or mixed vegetables
- Cooked bacon bits
- A pinch of Italian seasoning or paprika
How to Make Chicken Bubble Biscuit Bake
1. Preheat
Preheat oven to 190°C (375°F).
Grease a baking dish with butter or nonstick spray.
2. Make the Sauce
In a large bowl, whisk together cream of chicken soup, sour cream, milk, garlic powder, onion powder, salt, and pepper.
3. Assemble
Stir in chicken and half of the shredded cheese.
Gently fold in biscuit pieces until evenly coated.
4. Bake
Pour mixture into the prepared baking dish.
Sprinkle remaining cheese on top.
Bake uncovered for 35–40 minutes, until biscuits are cooked through and the top is golden and bubbly.
5. Rest & Serve
Let the casserole rest for 5–10 minutes before serving. This helps it set.
Tips for Best Results
- Cut biscuits evenly for consistent baking
- If top browns too fast, loosely cover with foil
- Use rotisserie chicken for speed
- Stir once halfway through baking for even cooking (optional)
Serving Ideas
- With a simple green salad
- Steamed green beans or broccoli
- Fresh fruit on the side
Storage
- Refrigerate leftovers up to 3 days
- Reheat in oven or microwave
- Not ideal for freezing (biscuits soften)
Final Thought
This Chicken Bubble Biscuit Bake Casserole is warm, creamy, and endlessly comforting—the kind of meal that brings everyone back to the table for seconds. Easy ingredients, simple steps, and guaranteed satisfaction.